Understanding and managing the complex balance between bleeding and thrombosis following cardiopulmonary bypass in paediatric cardiac surgical patients. (24th August 2021)

• Record Type: Journal Article
• Authors: Cohen, Jordan A.; Faraoni, David; Vener, David F.
• Is Part Of: Cardiology in the young. Volume 31:Number 8(2021)
• Page Start: 1251
• Page End: 1257
• Publication Date: 2021-08-24
• Subjects: Paediatric cardiac surgery -- anaesthesia -- bleeding -- thrombosis -- point-of-care testing; Pediatric cardiology -- Periodicals; 618.9212
• DOI: 10.1017/S1047951121001955
• Languages: English
• ISSNs: 1047-9511

Abstract

Abstract: Bleeding in the perioperative period of congenital heart surgery with cardiopulmonary bypass is associated with increased morbidity and mortality both from the direct effects of haemorrhage as well as the therapies deployed to restore haemostasis. Perioperative bleeding is complex and multifactorial with both patient and procedural contributions. Moreover, neonates and infants are especially at risk. The objective of this review is to summarise the evidence regarding bleeding management in paediatric surgical patients and identify strategies that might facilitate appropriate bleeding management while minimising the risk of thrombosis. We will address the use of standard and point-of-care tests, and the role of contemporary coagulation factors and other novel drugs.