Pathogenesis and prospects for therapeutic clinical application of noncoding RNAs in glaucoma: Systematic perspectives. Issue 10 (26th February 2021)

• Record Type: Journal Article
• Authors: Rong, Rong; Wang, Mengxiao; You, Mengling; Li, Haibo; Xia, Xiaobo; Ji, Dan
• Is Part Of: Journal of cellular physiology. Volume 236:Issue 10(2021)
• Page Start: 7097
• Page End: 7116
• Publication Date: 2021-02-26
• Subjects: circular RNAs -- glaucoma -- long noncoding RNAs -- microRNAs; Physiology -- Periodicals; Cell physiology -- Periodicals; 571.6
• DOI: 10.1002/jcp.30347
• Languages: English
• ISSNs: 0021-9541

Abstract

Abstract: Noncoding ribonucleic acids (ncRNAs) are an increasingly studied class of RNA molecules with extensive biological activities, including important roles in human development, health, and disease. Glaucoma is a neurodegenerative disease of the retina, and one of the leading causes of blindness worldwide. However, the specific roles of ncRNAs in the development and progression of glaucoma are unclear, and related reports are fragmented. An in‐depth understanding of ncRNAs participating in the pathogenesis and progression of glaucoma would be helpful for opening up new avenues to facilitate the early diagnosis and clinical treatment. Therefore, in this review, we aimed to discuss the current research progress, the potentialfuture clinical applications and the research limitations of three critical classes of ncRNAs in glaucoma, namely microRNAs, long noncoding RNAs, and circular RNAs. Abstract : We conducted a comprehensive and systematic summary of the existing works in noncoding RNAs (ncRNAs) and glaucoma, and an extensive discussion on the research directions and treatment prospects of ncRNAs in glaucoma.