Role of pyroptosis in atherosclerosis and its therapeutic implications. Issue 10 (23rd March 2021)

• Record Type: Journal Article
• Authors: He, Bin; Nie, Qiangqiang; Wang, Feng; Han, Yongxin; Yang, Bo; Sun, Mingsheng; Fan, Xueqiang; Ye, Zhidong; Liu, Peng; Wen, Jianyan
• Is Part Of: Journal of cellular physiology. Volume 236:Issue 10(2021)
• Page Start: 7159
• Page End: 7175
• Publication Date: 2021-03-23
• Subjects: anti‐inflammatory treatment -- atherosclerosis -- caspase‐1 -- GSDMD -- inflammation -- NLRP3 -- pyroptosis; Physiology -- Periodicals; Cell physiology -- Periodicals; 571.6
• DOI: 10.1002/jcp.30366
• Languages: English
• ISSNs: 0021-9541

Abstract

Abstract: Atherosclerosis is a significant cardiovascular burden and a leading cause of death worldwide, recognized as a chronic sterile inflammatory disease. Pyroptosis is a novel proinflammatory regulated cell death, characterized by cell swelling, plasma membrane bubbling, and robust release of proinflammatory cytokines (such as interleukin IL‐1β and IL‐18). Mounting studies have addressed the crucial contribution of pyroptosis to atherosclerosis and clarified the candidate therapeutic agents targeting pyroptosis for atherosclerosis. Herein, we review the initial characterization of pyroptosis, the detailed mechanisms of pyroptosis, current evidence about pyroptosis and atherosclerosis, and potential therapeutic strategies that target pyroptosis in the development of atherosclerosis. Graphical abstract: Mounting studies have addressed the crucial contribution of pyroptosis to atherosclerosis and clarified the candidate therapeutic agents targeting pyroptosis for atherosclerosis. Herein, we review the initial characterization of pyroptosis, the detailed mechanisms of pyroptosis, current evidence about pyroptosis and atherosclerosis, and potential therapeutic strategies that target pyroptosis in the development of atherosclerosis.