Profilin—A master coordinator of actin and microtubule organization in mammalian cells. Issue 10 (6th April 2021)

• Record Type: Journal Article
• Authors: Karlsson, Roger; Dráber, Pavel
• Is Part Of: Journal of cellular physiology. Volume 236:Issue 10(2021)
• Page Start: 7256
• Page End: 7265
• Publication Date: 2021-04-06
• Subjects: actin microtubule cross‐talk -- cell migration -- cytoarchitecture regulation -- cytoskeletal control -- profilin; Physiology -- Periodicals; Cell physiology -- Periodicals; 571.6
• DOI: 10.1002/jcp.30379
• Languages: English
• ISSNs: 0021-9541

Abstract

Abstract: The last two decades have witnessed a tremendous increase in cell biology data. Not least is this true for studies of the dynamic organization of the microfilament and microtubule systems in animal cells where analyses of the molecular components and their interaction patterns have deepened our understanding of these complex force‐generating machineries. Previous observations of a molecular cross‐talk between the two systems have now led to the realization of the existence of several intricate mechanisms operating to maintain their coordinated cellular organization. In this short review, we relate to this development by discussing new results concerning the function of the actin regulator profilin 1 as a control component of microfilament‐microtubule cross‐talk. Abstract : With the actin regulator profilin in focus, this review deals with actin‐microtubule cross‐talk and discusses how profilin contributes to the coordination of actin and microtubule organization in mammalian cells. In view of newly published data on the structure of the microtubule nucleating complex γ‐TuRC and its bound actin molecule, we further propose how profilin may balance microtubule nucleation at the centrosome.