Optimization of supercritical fluid extraction of asiaticoside from Centella asiatica using Central Composite Design (CCD). Issue 16 (2nd November 2021)

• Record Type: Journal Article
• Authors: Ruslan, Fatin Shazwani; Susanti, Deny; Taher, Muhammad; Mohammad, Nurul Farahain
• Is Part Of: Separation science and technology. Volume 56:Issue 16(2021)
• Page Start: 2766
• Page End: 2774
• Publication Date: 2021-11-02
• Subjects: Centella asiatica -- extraction -- asiaticoside -- optimization -- supercritical fluid extraction; Separation (Technology) -- Periodicals; 660.284205
• DOI: 10.1080/01496395.2020.1845208
• Languages: English
• ISSNs: 0149-6395

Abstract

ABSTRACT: The extraction of asiaticoside was performed using supercritical fluid extraction to produce highly concentrated extracts. The effects of three factors (co-solvent percentage, pressure, and temperature) on the asiaticoside content were screened using the Two-Level Factorial design and optimized using the Central Composite Design. Asiaticoside was extracted following the treatment combinations of three parameters, namely co-solvent (5–15%), temperature (70–90°C), and pressure (1–20 MPa). The optimized extraction parameters were identified at 10%, 10.5 MPa, and 80°C for co-solvent percentage, pressure, and temperature, respectively.