Copper-catalyzed radical ring-opening halogenation with HX. Issue 69 (10th August 2021)

• Record Type: Journal Article
• Authors: Liu, Shuai; Bai, Ming; Xu, Peng-Fei; Sun, Qing-Xin; Duan, Xin-Hua; Guo, Li-Na
• Is Part Of: Chemical communications. Volume 57:Issue 69(2021)
• Page Start: 8652
• Page End: 8655
• Publication Date: 2021-08-10
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d1cc03013b
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : An efficient copper-catalyzed radical ring-opening halogenation with HX (aq) is described. This protocol provides a practical access to distally chlorinated, brominated and iodinated alkyl ketones and alkyl nitriles with moderate to good yields. Abstract : An efficient copper-catalyzed radical ring-opening halogenation with HX (aq) is described. This protocol features redox-neutral conditions, green halogen sources, and a broad substrate scope, providing practical access to distally chlorinated, brominated and iodinated alkyl ketones and alkyl nitriles with moderate to good yields.