Hydrogel, a novel therapeutic and delivery strategy, in the treatment of intrauterine adhesions. Issue 33 (29th July 2021)

• Record Type: Journal Article
• Authors: Lv, Houyi; Wu, Bingbing; Song, Jianyuan; Wu, Wei; Cai, Wangyu; Xu, Jian
• Is Part Of: Journal of materials chemistry. Volume 9:Issue 33(2021)
• Page Start: 6536
• Page End: 6552
• Publication Date: 2021-07-29
• Subjects: Materials -- Periodicals; Chemistry, Analytic -- Periodicals; Biomedical materials -- Research -- Periodicals; 543.0284
• DOI: 10.1039/d1tb01005k
• Languages: English
• ISSNs: 2050-750X

Abstract

Abstract : The application of a hydrogel is showed in the treatment of IUAs as a physical barrier or novel therapeutic delivery system. Abstract : Intrauterine adhesions (IUAs) are caused by damage to the underlying lining of the endometrium. They' re related to disorder of endometrial repair. In recent years, hydrogels with controllable biological activity have been widely used for treating IUAs. They encapsulate estrogen, cytokines, cells, or exosomes, forming a delivery system to release therapeutic components for the treatment of IUAs. In addition, the hydrogel acting as a barrier can be degraded in the body automatically, reducing the risk of infection caused by secondary surgeries. In this review, we summarize the recent progress of hydrogels and their application in IUAs as both a novel alternative therapeutic and an artificial delivery strategy.