Defining the conditions for the development of the emerging class of FeIII-based MRI contrast agents. Issue 33 (26th July 2021)

• Record Type: Journal Article
• Authors: Baranyai, Zsolt; Carniato, Fabio; Nucera, Alessandro; Horváth, Dávid; Tei, Lorenzo; Platas-Iglesias, Carlos; Botta, Mauro
• Is Part Of: Chemical science. Volume 12:Issue 33(2021)
• Page Start: 11138
• Page End: 11145
• Publication Date: 2021-07-26
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/d1sc02200h
• Languages: English
• ISSNs: 2041-6520

Abstract

Abstract : An integrated 1 H and 17 O NMR relaxometric study on model systems allowed to highlight that the Fe(III) complexes might represent the best alternative to Gd-based MRI contrast agents at the magnetic fields of current and future clinical scanners. Abstract : Fe(iii ) complexes are attracting growing interest in chemists developing diagnostic probes for Magnetic Resonance Imaging because they leverage on an endogenous metal and show superior stability. However, in this case a detailed understanding of the relationship between the chemical structure of the complexes, their magnetic, thermodynamic, kinetic and redox properties and the molecular parameters governing the efficacy (relaxivity) is still far from being available. We have carried out an integrated 1 H and 17 O NMR relaxometric study as a function of temperature and magnetic field, on the aqua ion and three complexes chosen as reference models, together with theoretical calculations, to obtain accurate values of the parameters that control their relaxivity. Moreover, thermodynamic stability and dissociation kinetics of the Fe(iii ) chelates, measured in association with the ascorbate reduction behaviour, highlight their role and mutual influence in achieving the stability required for use in vivo .