Laser-induced switching of the biological activity of phosphonate molecules. (16th August 2021) - Kolesnikov, Ilya
Abstract : The effect of laser activation on butyrylcholinesterase inhibition by a series of phosphorylated arylaminomalonates with different substituents in the phenyl ring is demonstrated. Abstract : Butyrylcholinesterase inhibition and its enhancement as a result of laser irradiation are demonstrated for the first time for a series of phosphorylated arylaminomalonates. The effect of substituents in the phenyl group on butyrylcholinesterase inhibition and its laser-activated enhancement is revealed experimentally and confirmed by molecular dynamics and docking modelling.