Activatable photoacoustic/fluorescent dual-modal probe for monitoring of drug-induced liver hypoxia in vivo. Issue 69 (9th August 2021)

• Record Type: Journal Article
• Authors: Fan, Xiaopeng; Ren, Tianbing; Yang, Wen; Zhang, Xiaobing; Yuan, Lin
• Is Part Of: Chemical communications. Volume 57:Issue 69(2021)
• Page Start: 8644
• Page End: 8647
• Publication Date: 2021-08-09
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d1cc02999a
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : Effective monitoring of liver hypoxia is crucial for warning of drug-induced liver injury. Here, a novel photoacoustic/fluorescent dual-modal probe was rationally developed to image isoniazid-induced liver hypoxia through detecting nitroreductase. Abstract : Effective monitoring of liver hypoxia status is crucial for the detection and treatment of drug-induced liver injury. Here, a novel photoacoustic and fluorescent dual-modal probe (NO2 -CS ) was rationally developed and applied to image isoniazid-induced liver hypoxia through detecting the over-expressed nitroreductase.