Type I, II, and III Interferon Signatures Correspond to Coronavirus Disease 2019 Severity. (24th May 2021)

• Record Type: Journal Article
• Authors: Kim, Myung-Ho; Salloum, Shadi; Wang, Jeffrey Y; Wong, Lai Ping; Regan, James; Lefteri, Kristina; Manickas-Hill, Zachary; Gao, Ce; Li, Jonathan Z; Sadreyev, Ruslan I; Yu, Xu G; Chung, Raymond T
• Is Part Of: Journal of infectious diseases. Volume 224:Number 5(2021)
• Page Start: 777
• Page End: 782
• Publication Date: 2021-05-24
• Subjects: SARS-CoV-2 -- interferon-stimulated genes -- IRF-1; Communicable diseases -- Periodicals; Diseases -- Causes and theories of causation -- Periodicals; Medicine -- Periodicals; Communicable Diseases -- Periodicals; Electronic journals; 616.9
• DOI: 10.1093/infdis/jiab288
• Languages: English
• ISSNs: 0022-1899

Abstract

Abstract: We analyzed plasma levels of interferons (IFNs) and cytokines, and expression of IFN-stimulated genes in peripheral blood mononuclear cells in patients with coronavirus disease 2019 of varying disease severity. Patients hospitalized with mild disease exhibited transient type I IFN responses, while intensive care unit patients had prolonged type I IFN responses. Type II IFN responses were compromised in intensive care unit patients. Type III IFN responses were induced in the early phase of infection, even in convalescent patients. These results highlight the importance of early type I and III IFN responses in controlling coronavirus disease 2019 progression. Abstract : Patients hospitalized with mild coronavirus disease 2019 exhibited transient type I interferon responses, while intensive care unit (ICU) patients had prolonged type I interferon responses and compromised type II responses. Type III interferon responses were induced early during infection.