Pan-drug resistant Providencia rettgeri contributing to a fatal case of COVID-19. Issue 8 (27th August 2021)

• Record Type: Journal Article
• Authors: Mc Gann, Patrick; Geringer, Matthew R.; Hall, Lindsey R.; Lebreton, Francois; Markelz, Elizabeth; Kwak, Yoon I.; Johnson, Sheila; Ong, Ana C.; Powell, Aubrey; Tekle, Tsigereda; Bergman, Yehudit; Simner, Patricia J.; Bennett, Jason W.; Cybulski, Robert J.; White, Brian K.
• Is Part Of: Journal of medical microbiology. Volume 70:Issue 8(2021)
• Publication Date: 2021-08-27
• Subjects: cefiderocol resistance -- COVID-19 -- NDM carbapenemase -- Providencia rettgeri; Medical microbiology -- Periodicals; 616.9041
• DOI: 10.1099/jmm.0.001406
• Languages: English
• ISSNs: 0022-2615

Abstract

Abstract : Following prolonged hospitalization that included broad-spectrum antibiotic exposure, a strain of Providencia rettgeri was cultured from the blood of a patient undergoing extracorporeal membrane oxygenation treatment for hypoxic respiratory failure due to COVID-19. The strain was resistant to all antimicrobials tested including the novel siderophore cephalosporin, cefiderocol. Whole genome sequencing detected ten antimicrobial resistance genes, including the metallo-β-lactamase bla NDM-1, the extended-spectrum β-lactamase bla PER-1, and the rare 16S methyltransferase rmtB2 .