Normative placental structure in pregnancy using quantitative Magnetic Resonance Imaging. (1st September 2021)

• Record Type: Journal Article
• Authors: Andescavage, Nickie; Kapse, Kushal; Lu, Yuan-Chiao; Barnett, Scott D.; Jacobs, Marni; Gimovsky, Alexis C.; Ahmadzia, Homa; Quistorff, Jessica; Lopez, Catherine; Andersen, Nicole Reinholdt; Bulas, Dorothy; Limperopoulos, Catherine
• Is Part Of: Placenta. Volume 112(2021)
• Page Start: 172
• Page End: 179
• Publication Date: 2021-09-01
• Subjects: Placenta -- Magnetic resonance imaging (MRI) -- Structure -- Normative -- In-vivo; Magnetic Resonance Imaging (MRI) -- quantitative MRI (qMRI) -- appropriate for gestational age (AGA) -- single-shot fast spin echo (SSFSE) -- T2-weighted (T2W) -- pulsed gradient spin echo (PGSE) -- diffusion weighted image (DWI) -- apparent diffusion coefficient (ADC) -- intravoxel incoherent motion model (IVIM) -- diffusion coefficient (D) -- pseudo-diffusion coefficient (D*) -- perfusion fraction (f) -- short run emphasis (SRE) -- long run emphasis (LRE) -- Grey level non uniformity (GLNU) -- run length non uniformity (RLNU) -- short run low grey level emphasis (SRLGLE) -- long run high grey level emphasis (LRHGLE) -- small for gestational age (SGA) -- fetal growth restriction (FGR) -- placenta accreta disorders (PAS); Placenta -- Periodicals; Reproduction -- Periodicals; Placenta -- Periodicals; Placenta -- Périodiques; Reproduction -- Périodiques; 612.63
• DOI: 10.1016/j.placenta.2021.07.296
• Languages: English
• ISSNs: 0143-4004

Abstract

Abstract: Introduction: To characterize normative morphometric, textural and microstructural placental development by applying advanced and quantitative magnetic resonance imaging (qMRI) techniques to the in-vivo placenta. Methods: We enrolled 195 women with uncomplicated, healthy singleton pregnancies in a prospective observational study. Women underwent MRI between 16- and 40-weeks' gestation. Morphometric and textural metrics of placental growth were calculated from T2-weighted (T2W) images, while measures of microstructural development were calculated from diffusion-weighted images (DWI). Normative tables and reference curves were constructed for each measured index across gestation and according to fetal sex. Results: Data from 269 MRI studies from 169 pregnant women were included in the analyses. During the study period, placentas undergo significant increases in morphometric measures of volume, thickness, and elongation. Placental texture reveals increasing variability with advancing gestation as measured by grey level non uniformity, run length non uniformity and long run high grey level emphasis. Placental microstructure did not vary with gestational age. Placental elongation was the only metric that differed significantly between male and female fetuses. Discussion: We report quantitative metrics of placental morphometry, texture and microstructure in a large cohort of healthy controls during the second and third trimesters of pregnancy. These measures can serve as normative references of in-vivo placental development to better understand placental function in high-risk conditions and allow for the early detection of placental mal-development. Highlights: Normative in vivo references of placental structure are limited. qMRI can provide accurate, non-invasive measures of placental structure. Normative curves of placental morphometry are presented for singleton gestations. Normative curves of placental texture are presented for singleton gestations. Normative curves of placental diffusion are presented for singleton gestations.