Simple and efficient method for producing high radionuclidic purity 111In using enriched 112Cd target. (October 2021)

• Record Type: Journal Article
• Authors: Gao, Jing; Liao, Zhonghui; Liu, Weihao; Hu, Yingjiang; Ma, Huan; Xia, Lingting; Li, Feize; Lan, Tu; Yang, Yuanyou; Yang, Jijun; Liao, Jiali; Liu, Ning
• Is Part Of: Applied radiation and isotopes. Volume 176(2021)
• Publication Date: 2021-10
• Subjects: Enriched 112Cd -- 111In -- Production -- Purification -- Recovery; Radiology -- Periodicals; Radiation -- Industrial applications -- Periodicals; Nuclear chemistry -- Periodicals; Internet resource; Periodical; 660.298
• DOI: 10.1016/j.apradiso.2021.109828
• Languages: English
• ISSNs: 0969-8043

Abstract

Abstract: In this work, a simple and efficient method for producing high radionuclidic purity 111 In from an enriched 112 Cd target was developed. The enriched 112 Cd metal target formed by cyanide-free electroplating was bombarded with protons of 21 MeV in a CS-30 cyclotron. Then, we explored a purification scheme using CL-P204 cation exchange resin wherein 98% of the 111 In in the bombarded target could be extracted in less than 1 h. The purified 111 In in the form of [ 111 In]In-chloride had a high radionuclidic purity (99.9%) and a low impurity concentration (<1.2 ppm). The yield of 111 In via the reaction of 112 Cd (p, 2n) 111 In was measured to be 222 ± 5 MBq/μA∙h. In addition, a chemical procedure for collecting the unreacted 112 Cd at a recovery rate of 96.6% was explored. Highlights: Production of high radionuclidic purity 111 In using enriched 112 Cd target. Purification of the final 111 In was achieved in 60 min with recovery yields >98%. A simple method for recovering the unreacted 112 Cd at a recovery rate of 96.6% was explored.