Cobalt(II) complexes derived from a 2-aminobenzimidazole-thiazoline ligand: Synthesis, characterization, crystal structures and antimicrobial activity studies. (1st October 2021)

• Record Type: Journal Article
• Authors: Moreno-Alvero, M.; Luna-Giles, F.; Barros-García, F.J.; Viñuelas-Zahínos, E.; Fernández-Calderón, M.C.
• Is Part Of: Polyhedron. Volume 207(2021)
• Publication Date: 2021-10-01
• Subjects: 2-aminobenzimidazole derivatives -- Thiazoline -- Cobalt(II) complexes -- Antimicrobial activity -- Crystal structures; Chemistry, Inorganic -- Periodicals; Chimie inorganique -- Périodiques; Organometaalverbindingen; Anorganische chemie; 546.05
• DOI: 10.1016/j.poly.2021.115390
• Languages: English
• ISSNs: 0277-5387

Abstract

Graphical abstract: Crystal structures of a 2-aminobenzimidazole-thiazoline derivative, which acts as a monodentate ligand, and its Co(II) complexes were determined. Antimicrobial activity of the compounds was studied towards six bacteria, both gram-positive and gram-negative, showing more activity against gram-positive bacteria. Co(II) complexes showed activity on different bacteria than the free ligand. Highlights: Co(II) complexes with benzimidazole-thiazoline derivative ligand. All compounds have been characterized by single crystal X-ray diffraction. Antimicrobial activity against gram positive/negative bacteria. Co(II) complexes showed activity on different bacteria than the free ligand. Abstract: As part of our ongoing studies related with the coordination chemistry of 2-thiazoline derivatives with transition ions, we report the synthesis of a new class of structurally novel complexes containing in their structures a 2-aminobenzimidazole ring. The resulting compound, 2-(2-aminobenzimidazole-1-yl)-2-thiazoline (BzTn), and two cobalt(II) complexes have been structurally characterized by means of physical measurements. The crystal structures of BzTn, [CoCl2 (BzTn)2 ] (1 ) and [CoBr2 (BzTn)2 ] (2 ) have been determined by single crystal X-ray diffraction. In both Co(II) complexes, BzTn acts as a monodentate ligand through nitrogen atom of benzimidazole ring. The distorted tetrahedral environmental around the Co(II) ions is completed with two halide ions. Besides that, the newly synthesized compounds were screened for their antimicrobial activity against 6 strains of bacteria: S. aureus, E. coli, S. epidermidis. B. subtilis, E. faecalis y P. aeruginosa.