Anti-NMDAR encephalitis in a 19 year old female patient with ovarian teratoma: A case report. (July 2021)

• Record Type: Journal Article
• Authors: El Hanna, Johnny; Quenum, Codjo; Arsalane, Abdelilah
• Is Part Of: European journal of obstetrics and gynecology and reproductive biology X. Volume 11(2021)
• Publication Date: 2021-07
• Subjects: Encephalitis -- Autoimmune -- Anti-N-Methyl-d-Aspartate -- Ovarian teratoma
• DOI: 10.1016/j.eurox.2021.100129
• Languages: English
• ISSNs: 2590-1613

Abstract

Abstract: Background: Anti -N- Methyl-d -Aspartate encephalitis is a subcategory of auto-immune encephalitis. It is known for its aggressive presenting symptoms and rapid deterioration, yet it is treatment responsive. It is associated in 50 % to ovarian teratoma. Case: We report the case of a 19 year old female patient presenting for a psychiatric disorder of sudden onset with rapid deterioration. Neurologic imaging was in favor of encephalitis, and CSF studies revealed Anti NMDA receptors. Further abdominal imaging showed a right ovarian teratoma of 4 cm. Laparoscopic ovarian cyst resection was done, and corticotherapy, IVIG and anticonvulsants were given. We report complete resolution of symptoms after 7 months. Conclusion: Anti-NMDA receptor encephalitis with ovarian teratoma is a rare entity with rapid deterioration. Early diagnosis, surgical resection and proper medical treatment are essential for the management of this disease.