Sequential C–H activation enabled expedient delivery of polyfunctional arenes. Issue 65 (23rd July 2021) - Ouyang, Wensen
Abstract : A sequential C–H activation of versatile imidates was realized, affording to polyfunctional arenes was developed, which were key precursors for drugs and materials. Abstract : Modular construction of polyfunctional arenes from abundant feedstocks stands as an unremitting pursue in synthetic chemistry, accelerating the discovery of drugs and materials. Herein, using the multiple C–H activation strategy with versatile imidate esters, the expedient delivery of molecular libraries of densely functionalized sulfur-containing arenes was achieved, which enabled the concise construction of biologically active molecules, such as Bipenamol.