An "AND"-logic-gate-based fluorescent probe with dual reactive sites for monitoring extracellular methylglyoxal level changes of activated macrophages. Issue 66 (27th July 2021)

• Record Type: Journal Article
• Authors: Wang, Wenli; Chen, Junwei; Ma, Huijuan; Xing, Wanjin; Lv, Nan; Zhang, Baoning; Xu, Huan; Wang, Wei; Lou, Kaiyan
• Is Part Of: Chemical communications. Volume 57:Issue 66(2021)
• Page Start: 8166
• Page End: 8169
• Publication Date: 2021-07-27
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d1cc01859k
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : An "AND"-logic-gate-based fluorescent probe with reversible guanidino and irreversible o -phenylenediamino reactive sites for monitoring extracellular methylglyoxal levels upon macrophage activation. Abstract : An "AND"-logic-gate-based fluorescent probe NAP-DCP-4 with dual reactive sites is reported, which has improved selectivity for methylglyoxal over glyoxal, featuring formaldehyde-enhanced methylglyoxal detection and irreversible and reversible turn-on fluorescence responses at different excitation wavelengths. Its cell-impermeability enables facile monitoring of extracellular methylglyoxal level changes in the supernatant of activated macrophages.