Hard-to-heal wound treated with Integra Flowable Wound Matrix: analysis and clinical observations. (2nd August 2021)

• Record Type: Journal Article
• Authors: Cammarota, Marcella; D'Agostino, Antonella; Campitiello, Ferdinando; Mancone, Manfredi; Ricci, Giulia; Corte, Angela Della; Guerniero, Raffaella; Stellavato, Antonietta; Schiraldi, Chiara; Canonico, Silvestro
• Is Part Of: Journal of wound care. Volume 30:Number 8(2021)
• Page Start: 644
• Page End: 652
• Publication Date: 2021-08-02
• Subjects: angiogenic process -- clinical observations -- dermal substitutes -- diabetes -- dressing -- healing process -- infection -- Integra Flowable Wound Matrix -- molecular and histological analysis -- tunnelling skin wound -- ulcer -- wound; Wounds and injuries -- Treatment -- Periodicals; Wound healing -- Periodicals; 617.1
• DOI: 10.12968/jowc.2021.30.8.644
• Languages: English
• ISSNs: 0969-0700

Abstract

Abstract : Skin healing defects severely impair the quality of life of millions of people and burden healthcare systems globally. The therapeutic approach to these pathologies still represents a challenge. Novel scaffolds, used as dermal substitutes, possibly represent a promising strategy in complex wound management. Integra Flowable Wound Matrix (IFWM) is composed of a lyophilised, micronised form of collagen/chondroitin sulphate matrix, already used in regenerative medicine and endorsed in the therapy of diabetic foot lesions. In this paper, IFWM was applied to a tunnelling hard-to-heal skin lesion in order to restore tissue integrity. Although the different phases of skin wound healing are well established, the molecular mechanism underpinning IFWM-induced tissue repair are almost unknown. Here, we report, for the first time, the comparative analysis of molecular, histological and clinical observations of the healing process of a hard-to-heal tunnelling skin wound. The therapeutic success of this clinical case allowed us to recommend the use of IFWM as a tissue substitute in this rare type of hard-to-heal wound in which the high inflammatory status hampered the natural healing process.