Synthesis, evaluation and modeling of some triazolothienopyrimidinones as anti-inflammatory and antimicrobial agents. (June 2017)

• Record Type: Journal Article
• Authors: Bekhit, Adnan A; Farghaly, Ahmed M; Shafik, Ragab M; Elsemary, Mona MA; El-Shoukrofy, Mai S; Bekhit, Alaa El-Din A; Ibrahim, Tamer M
• Is Part Of: Future medicinal chemistry. Volume 9:Number 9(2017)
• Page Start: 881
• Page End: 897
• Publication Date: 2017-06
• Subjects: dual anti-inflammatory antimicrobial activities -- human COX-1 and COX-2 enzymatic assay -- molecular modeling studies -- pyrazole -- triazolothienopyrimidinone derivatives; Pharmaceutical chemistry -- Periodicals; 615.19005
• DOI: 10.4155/fmc-2016-0242
• Languages: English
• ISSNs: 1756-8919

Abstract

Aim: New triazolotetrahydrobenzothienopyrimidinone derivatives were synthesized.Experimental : Their structures were confirmed, and their anti-inflammatory, antimicrobial activities and ulcerogenic potentials were evaluated.Results: Compounds7a, 10a and11a showed minimal ulcerogenic effect and high selectivity toward human recombinant COX-2 over COX-1 enzyme with IC50 values of 1.39, 1.22 and 0.56 μM, respectively. Their docking outcome correlated with their biological activity and confirmed the high selectivity binding toward COX-2. Compound12b displayed antimicrobial activity comparable to that of ampicillin against Escherichia coli while compounds6 and11c were similar to ampicillin against Staphylococcus aureus . In addition, compounds7a, 9a, 10b and11c showed dual anti-inflammatory/antimicrobial activities.Conclusion: This work represents a promising matrix for developing new potential anti-inflammatory, antimicrobial and dual antimicrobial/anti-inflammatory candidates.