Recent advances in gossypol derivatives and analogs: a chemistry and biology view. (July 2017)

• Record Type: Journal Article
• Authors: Lu, Yuzhi; Li, Jun; Dong, Chun-E; Huang, Jian; Zhou, Hai-Bing; Wang, Wei
• Is Part Of: Future medicinal chemistry. Volume 9:Number 11(2017)
• Page Start: 1243
• Page End: 1275
• Publication Date: 2017-07
• Subjects: antiapoptotic -- antitumor -- Bcl-2 inhibitor -- gossypol -- gossypol derivatives -- natural product chemistry -- polyphenols -- scaffold hopping -- structure–activity relationship -- synthetic chemistry; Pharmaceutical chemistry -- Periodicals; 615.19005
• DOI: 10.4155/fmc-2017-0046
• Languages: English
• ISSNs: 1756-8919

Abstract

Gossypol as a natural occurring polyphenol has been studied in a wide range of therapeutic contexts for a long time. The chemical modifications on gossypol were limited due to the unique chemical properties of polyphenols. The design and synthesis of gossypol derivatives and the exploration of their biological activities are the interest of the synthetic chemists, medicinal chemists and pharmacologists. Thus, the progress of diverse gossypol derivatives and analogs' synthesis, biological activities, mechanism elucidation and drug discovery based on gossypol scaffold is summarized. Graphical abstract: