Synthesis and testing of polymer grafted mesoporous silica as glucose-responsive insulin release drug delivery systems. (15th August 2021)

• Record Type: Journal Article
• Authors: Huang, Qiao; Yu, Haojie; Wang, Li; Shen, Di; Chen, Xiang; Wang, Nan
• Is Part Of: European polymer journal. Volume 157(2021)
• Publication Date: 2021-08-15
• Subjects: Glucose-responsive -- Phenylboronic acid -- Mesoporous silica -- Insulin -- Drug delivery; Polymers -- Periodicals; Polymerization -- Periodicals; Polymères -- Périodiques; Polymérisation -- Périodiques; Polymerization; Polymers; Periodicals; Electronic journals; 547.705
• DOI: 10.1016/j.eurpolymj.2021.110651
• Languages: English
• ISSNs: 0014-3057

Abstract

Graphical abstract: Highlights: Glucose-responsive release of insulin based on polymer-grafted mesoporous silica. The system showed glucose-responsive property at 37 °C and pH = 7.4. The different glucose-responsive properties were caused by two polymer coatings. Abstract: Stimuli-responsive materials based on mesoporous silica have been widely studied for the controlled release of drugs. Glucose-responsive systems play a vital role in the controlled release of insulin because they can smartly adjust the amount of released insulin in response to the fluctuational blood glucose concentration. Here, the mesoporous silica (MS) was modified with 3-fluoro-4-carboxyphenylboronic acid (FCPBA) to prepare phenylboronic acid-modified mesoporous silica (MS-FCPBA). N- acryloyl glucosamine (AGA) was copolymerized with N- isopropyl acrylamide (NIPAM) and acrylic acid (AAc) respectively to synthesize two polymers with diol groups, noted as P(NIPAM- co -AGA) and P(AAc- co -AGA) respectively. Since the phenylboronic acid group can form a borate ester bond with the diol group, the polymers were coated on the surface of insulin-loaded MS-FCPBA to obtain the insulin release systems. The results showed that the loading capacity and encapsulation efficiency of insulin could reach 14.7% and 85.9%, respectively. The two systems exhibited different glucose-responsive performance.