Dissecting the molecular control of Interleukin 6 signaling using the M1 cell line. (October 2021)

• Record Type: Journal Article
• Authors: Morris, Rhiannon; Hilton, Douglas J.; Jarratt, Andrew; Babon, Jeffrey J.
• Is Part Of: Cytokine. Volume 146(2021)
• Publication Date: 2021-10
• Subjects: Cytokine -- IL-6 -- IL-6 Signaling -- JAK/STAT -- M1 cells; G-CSF granulocyte colony stimulating factor -- GM-CSF granulocyte macrophage colony stimulating factor -- GP130 glycoprotein 130 kDa -- IFN interferon -- IL interleukin -- IL-6Rα IL-6 receptor chain alpha -- IL6ST IL-6 family cytokine signal transducer -- JAK/STAT Janus Kinase-Signal Transducer and Activator of Transcription -- LIF leukemia inhibitor factor -- MAPK mitogen activated protein kinase -- MARCH membrane-associated RING-CH -- OSM onconstatin M -- PI3K phosphoinositide 3 kinase -- PTP1B protein tyrosine phosphatase 1B -- SOCS suppressor of cytokine signaling -- TC-PTP T-cell protein tyrosine phospahatse -- TPO thrombopoietin -- TYK2 tyrosine kinase 2 -- WT Wild-Type; Cytokines -- Periodicals; 571.844
• DOI: 10.1016/j.cyto.2021.155624
• Languages: English
• ISSNs: 1043-4666

Abstract

Abstract: Interleukin 6 is the classical member of the IL-6 family of cytokines which triggers activation of the JAK/STAT signaling cascade in cells. IL-6 is a pleiotropic cytokine that acts on many cell types and plays a critical role in immune responses, inflammation, and haematopoiesis. Our understanding of the molecular mechanisms governing IL-6 signaling has been aided by numerous studies of this signal transduction pathway, including those utilising the M1 cell line. Here we discuss the studies that we and others have undertaken using the M1 line to examine IL-6 inducible genes, particularly those targets that acts as negative regulators of signaling. Finally, we present a model for the current understanding of the IL-6 signaling pathway at a structural and mechanistic level.