The effect of vitamin D supplementation on flow-mediated dilatation, oxidized LDL and intracellular adhesion molecule 1 on type 2 diabetic patients with hypertension: A randomized, placebo-controlled, double-blind trial. Issue 4 (July 2021)

• Record Type: Journal Article
• Authors: Qasemi, Reyhaneh; Ghavamzadeh, Saeid; Faghfouri, Amir Hossein; Valizadeh, Neda; Mohammadi, Afshin; Sayyadi, Hojjat
• Is Part Of: Diabetes & metabolic syndrome. Volume 15:Issue 4(2021)
• Publication Date: 2021-07
• Subjects: Diabetes mellitus -- Vitamin D -- Hypertension -- Flow-mediated dilatation -- Oxidized LDL -- Intracellular adhesion molecule 1; Diabetes -- Periodicals; Metabolism -- Disorders -- Periodicals; Diabetes Mellitus -- Periodicals; Metabolic Diseases -- Periodicals; Diabète -- Périodiques; Métabolisme, Troubles du -- Périodiques; Endocrinologie -- Périodiques; Diabète -- Physiopathologie -- Périodiques; Diabetes; Metabolism -- Disorders; Electronic journals; Periodicals; 616.462
• DOI: 10.1016/j.dsx.2021.102200
• Languages: English
• ISSNs: 1871-4021

Abstract

Abstract: Aims: Current study aimed to evaluate the effect of vitamin D supplementation on flow-mediated dilatation (FMD), oxidized LDL (oxLDL) and intracellular adhesion molecule 1 (ICAM1) in type 2 diabetic patients with hypertension. Methods: In a double-blinded, placebo-controlled trial, 44 patients were randomly divided into vitamin D group (2000 IU/d, n = 23) and placebo group (control, n = 21) for 12 weeks. Vascular function with FMD, Serum 25-OH vitamin D, oxLDL and ICAM1 were assessed at the baseline and after the intervention. This clinical trial was registered at Iranian Registry of Clinical Trials (IRCT20191223045861N1). Results: In intervention group serum level of vitamin D increased from 32.42 ± 10.56 to 40.45 ± 12.94 ( p < 0.001). In the vitamin D group, oxLDL and ICAM1 significantly decreased and FMD increased significantly in both groups ( p < 0.001). The level of oxLDL ( p = 0.017) and ICAM1 ( p < 0.001) were significantly lower in the vitamin D group than the placebo group and FMD ( p < 0.001) was significantly higher in the vitamin D group. Conclusions: Vitamin D supplementation of 2000 IU/d for 12 weeks can improve endothelial function and decrease ICAM1 and oxLDL in type 2 diabetic patients with hypertension. Highlights: Vitamin D supplementation can improve endothelial function in diabetic patients with hypertension. Vitamin D supplementation has amending effects on ICAM1 and ox-LDL levels in diabetic patients with hypertension. Vitamin D supplementation can be introduced as an adjunct therapy in diabetic patients with hypertension.