"Vitamin D supplementation and COVID-19 treatment: A systematic review and meta-analysis". Issue 4 (July 2021)

• Record Type: Journal Article
• Authors: Rawat, Dimple; Roy, Avishek; Maitra, Souvik; Shankar, Vivek; Khanna, Puneet; Baidya, Dalim Kumar
• Is Part Of: Diabetes & metabolic syndrome. Volume 15:Issue 4(2021)
• Publication Date: 2021-07
• Subjects: Vitamin-D -- COVID-19 -- COVID pneumonia -- SARS-CoV-2; Diabetes -- Periodicals; Metabolism -- Disorders -- Periodicals; Diabetes Mellitus -- Periodicals; Metabolic Diseases -- Periodicals; Diabète -- Périodiques; Métabolisme, Troubles du -- Périodiques; Endocrinologie -- Périodiques; Diabète -- Physiopathologie -- Périodiques; Diabetes; Metabolism -- Disorders; Electronic journals; Periodicals; 616.462
• DOI: 10.1016/j.dsx.2021.102189
• Languages: English
• ISSNs: 1871-4021

Abstract

Abstract: Background: Vitamin-D is an immune-modulator which might be linked to disease severity by SARS-CoV-2. Methods: Meta-analysis of RCTs and quasi-experimental studies, evaluating the role of vitamin-D supplementation in COVID patients was done. Results: Total 5 studies (3 RCTs and 2 Quasi-experimental) including n = 467 patients were included. Vitamin D didn't reduce mortality (RR 0.55, 95%CI 0.22 to 1.39, p = 0.21), ICU admission rates (RR 0.20, 95% CI 0.01–4.26, p = 0.3) and need for invasive ventilation (RR 0.24, 95% CI 0.01–7.89, p = 0.42). Conclusion: No significant difference with vitamin-D supplementation on major health related outcomes in COVID-19. Well-designed RCTs are required addressing this topic. Highlights: Efficacy of vitamin-D in patients with COVID-19 is controversial. Previous RCTs demonstrated contrasting results. The meta-analysis did not show any outcome benefit with vitamin D supplementation with low certainty of evidence.