Oncostatin M is a novel biomarker for coronary artery disease – A possibility as a screening tool of silent myocardial ischemia for diabetes mellitus. (August 2021)

• Record Type: Journal Article
• Authors: Ikeda, Shohei; Sato, Koichi; Takeda, Morihiko; Miki, Keita; Aizawa, Kentaro; Takada, Tsuyoshi; Fukuda, Koji; Shiba, Nobuyuki
• Is Part Of: IJC heart & vasculature. Volume 35(2021)
• Publication Date: 2021-08
• Subjects: OSM -- Coronary artery diseases -- Silent myocardial ischemia -- Biomarker -- Diabetes mellitus; BNP brain natriuretic peptide -- BMI body mass index -- CACS coronary computed tomography calcium score -- CAD coronary artery disease -- CAG coronary angiography -- DM diabetes mellitus -- EF ejection fraction -- FFR fractional flow reserve -- HDL-C high-density lipoprotein-cholesterol -- HF heart failure -- iFR instantaneous wave-free ratio -- LDL-C low-density lipoprotein-cholesterol -- LVEF left ventricular ejection fraction -- OSM oncostatin M -- PCI percutaneous coronary intervention -- YAP yes-associated protein; Cardiovascular system -- Diseases -- Periodicals; Cardiovascular system -- Pathophysiology -- Periodicals; 616.1005
• DOI: 10.1016/j.ijcha.2021.100829
• Languages: English
• ISSNs: 2352-9067

Abstract

Abstract: Objective: Oncostatin M (OSM) is an inflammatory cytokine of the interleukin-6 family which plays a crucial role in the pathogenesis of atherosclerosis. Therefore, we tested our hypothesis that serum OSM levels are increased in patients with coronary artery diseases (CAD). Methods and results: Serum OSM level was measured by sandwich technique immunoassay in 315 consecutive patients and who underwent coronary angiography at the International University of Health and Welfare Hospital from April 2019 to March 2021. A diagnosis of CAD was made in 169 patients. Serum OSM levels were significantly higher in patients with significant coronary stenosis compared to those without it. [123.0 ± 46.7 pg/mL (n = 169) vs. 98.3 ± 47.9 pg/mL (n = 146), p < 0.001]. A positive correlation was noted between serum OSM levels and severity and complexity of coronary stenosis. Importantly, the coronary revascularization significantly decreased the serum OSM levels. We furthermore detected a positive correlation between serum OSM levels and HbA1c levels. Finally, our data suggested that 120 pg/mL of serum OSM was the potential cutoff value for screening of silent myocardial ischemia related with diabetic mellitus (DM). Conclusion: Serum OSM can be a novel biomarker for CAD and may be useful for the screening of asymptomatic CAD in patients with DM.