Cytokine profiles in children with acute intussusception in South Africa. (October 2021)

• Record Type: Journal Article
• Authors: Bessey, Theresa K.; Parashar, Umesh D.; Tate, Jacqueline E.; Madhi, Shabir A.; Jiang, Baoming; Groome, Michelle J.
• Is Part Of: Cytokine. Volume 146(2021)
• Publication Date: 2021-10
• Subjects: Intussusception -- Surveillance -- C-reactive protein -- Pro-inflammatory cytokines -- Rotavirus vaccination -- Acute Gastroenteritis -- IFN-γ; IS Intussusception -- AGE Acute gastroenteritis -- RV Rotavirus; Cytokines -- Periodicals; 571.844
• DOI: 10.1016/j.cyto.2021.155639
• Languages: English
• ISSNs: 1043-4666

Abstract

Abstract: Serum specimens of children hospitalized with acute intussusception (IS; n = 407) were analyzed for various pro- and anti-inflammatory cytokines to identify host markers specifically for IS compared to other surgical conditions (n = 235) or acute gastroenteritis (AGE; n = 68) in a cross-sectional study design. We showed that children with IS had elevated levels of pro-inflammatory cytokines IFN-γ, TNF-α, MIP-1β, IL-1β, IL-2, IL-6, IL-7, IL-8, and IL-17 as well as anti-inflammatory cytokines IL-1RA, IL-4, IL-5, and IL-13 compared to those admitted with surgical conditions or AGE symptoms, indicating these cytokines as markers for IS. In addition, we showed an increase in C-reactive protein (CRP) levels in children with IS. This study is the first to show a broad cytokine profile and identify cytokine markers in children with IS.