O20.3 Hiv transmission in male serodiscordant couples in australia, thailand and brazil. (13th September 2015)

• Record Type: Journal Article
• Authors: Bavinton, BR; Jin, F; Prestage, G; Zablotska, IB; Grinsztejn, B; Phanuphak, N; Moore, R; Koelsch, KK; Grulich, AE
• Is Part Of: Sexually transmitted infections. Volume 91(2015)Supplement 2
• Page Start: A70
• Page End: A71
• Publication Date: 2015-09-13
• Subjects: Sexually transmitted diseases -- Periodicals; HIV infections -- Periodicals; 616.951005
• DOI: 10.1136/sextrans-2015-052270.189
• Languages: English
• ISSNs: 1368-4973

Abstract

Abstract : Background: Numerous prospective studies have demonstrated that HIV transmission is greatly reduced in heterosexual HIV serodiscordant couples when the HIV-positive partner (HPP) is receiving combination anti-retroviral therapy (cART) with undetectable viral load (UVL). Comparable data in homosexual male serodiscordant couples (HM-SDC) are extremely limited. We report a pre-specified interim analysis of the relationship between UVL and HIV transmission in the Opposites Attract observational cohort study of HM-SDC in Australia, Bangkok and Rio de Janeiro. Methods: HM-SDC reporting regular anal intercourse with each other were recruited through clinical sites. Detailed information on sexual risk behaviours was collected at each visit from the HIV-negative partner (HNP). HNPs were tested at baseline and follow-up for HIV antibodies and STIs (sexually transmitted infections), and HPPs for HIV viral load and STIs. Incidence rates were calculated per couple-year of follow-up (CYFU) using person-year methods, and stratified by whether different forms of condomless anal intercourse (CLAI) were reported. UVL was defined as <200 copies/mL. One-sided confidence intervals (CI) were calculated using the exact Poisson method. Linked HIV transmission in couples was defined by phylogenetic analysis. Results: By December 2014, 234 HM-SDC were enrolled: 135 from Australia, 52 from Bangkok and 47 from Rio de Janeiro. There were a total of 150.0 CYFU in 152 couples with at least one follow-up visit of whom 65 (42.8%) were in a non-monogamous relationship. At baseline, 84.2% of HPPs were on cART and in total 82.9% had UVL. STI prevalence was 11.2% in HPPs and 6.6% in HNPs. There were 90.8 CYFU in periods where CLAI was reported with a total of 5, 905 acts of CLAI in 88 couples. There were no linked HIV transmissions. The upper limit of the 95% CI of the transmission rate was 4.06/100 CYFU for periods in which CLAI was reported, and 6.46/100 CYFU for periods in which receptive CLAI was reported. Conclusions: There were no linked HIV transmissions in 150 CYFU in these HM-SDC, despite close to 6, 000 acts of CLAI. The upper confidence limit of the transmission rate during follow-up in periods during which CLAI was occurring was 4.06/100 CYFU. These data add to emerging evidence that the rate of HIV transmission in HM-SDC is very low when the HIV-positive partner is on ART. Further follow-up of a larger sample size is required to accurately delineate any residual risk.