Loading and elution characteristics of quadrasphere microspheres loaded with bevacizumab. (August 2017)

• Record Type: Journal Article
• Authors: Oselkin, Martin; Sedora-Roman, Neda I; Pukenas, Bryan A; Kung, David; Hurst, Robert W
• Is Part Of: Therapeutic delivery. Volume 8:Number 9(2017)
• Page Start: 747
• Page End: 751
• Publication Date: 2017-08
• Subjects: Avastin® -- bevacizumab, drug-eluting beads -- drug-eluting particles -- embolization -- microspheres; Drug delivery systems -- Periodicals; Therapeutics -- Periodicals; 615.6
• DOI: 10.4155/tde-2017-0036
• Languages: English
• ISSNs: 2041-5990

Abstract

Aim: Super absorbent polyvinyl alcohol-sodium acrylate copolymer microspheres, Quadrasphere microspheres (QSM), are commonly used for drug-eluting bead therapy, however, the literature only reports its use with small molecule chemotherapeutics. This study evaluates the loading and elution characteristics of bevacizumab-loaded QSM.Methods & results: A single vial of QSM was reconstituted with 200 mg of bevacizumab. Drug concentration was determined by ELISA immunoassay. At approximately 90 min, there was maximal loading at 59% of the starting dose. In vitro elution demonstrated 52% of bound bevacizumab was released within the first hour and 68% by 16 h.Conclusion: Bevacizumab can load onto QSM and elute over time. This targeted delivery vehicle may potentially result in more effective treatment and fewer complications related to systemic toxicity.