Classification of breast cancer histopathological image with deep residual learning. Issue 3 (28th January 2021)

• Record Type: Journal Article
• Authors: Hu, Chuhan; Sun, Xiaoyan; Yuan, Zhenming; Wu, Yingfei
• Is Part Of: International journal of imaging systems and technology. Volume 31:Issue 3(2021)
• Page Start: 1583
• Page End: 1594
• Publication Date: 2021-01-28
• Subjects: data augmentation -- histopathological image -- myResNet‐34 -- stain normalization; Imaging systems -- Periodicals; Image processing -- Periodicals; 621.367
• DOI: 10.1002/ima.22548
• Languages: English
• ISSNs: 0899-9457

Abstract

Abstract: Breast cancer has high incidences and mortality rates in women worldwide. Malignancy could be detected manually by experienced pathologists based on Hematoxylin and Eosin (H&E) stained images. However, it is time‐consuming and experience‐dependent, making early diagnosis a big challenge. In this paper, a methodology for breast cancer classification based on histopathological images with deep learning was described. A residual learning‐based convolutional neural network named myResNet‐34 was designed for malignancy‐and‐benign classification. In addition, an algorithm automatically generating the target image for stain normalization was proposed, which eliminated the bias caused by manual selection of the reference image. Elastic distortion was introduced and combined with affine transformation for data augmentation considering the characteristics of the H&E images. Experiments were conducted on BreakHis dataset with the proposed framework. Promising results were achieved with an average classification accuracy of around 91% on image‐level classification. Results indicated that both our data augmentation and stain normalization effectively improved the classification accuracy by 2‐3%.