Maternal vitamin D, oxidative stress, and pre‐eclampsia. Issue 3 (21st January 2021)

• Record Type: Journal Article
• Authors: Wei, Shu Qin; Bilodeau, Jean‐François; Julien, Pierre; Luo, Zhong‐Cheng; Abenhaim, Haim A.; Bi, Wei Guang; Nuyt, Anne Monique; Leduc, Line; Audibert, François; Fraser, William D.
• Is Part Of: International journal of gynaecology and obstetrics. Volume 154:Issue 3(2021)
• Page Start: 444
• Page End: 450
• Publication Date: 2021-01-21
• Subjects: 25‐hydroxyvitamin D -- F2‐isoprostanes -- oxidative stress -- pre‐eclampsia -- vitamin D; Gynecology -- Periodicals; Obstetrics -- Periodicals; Electronic journals; 618
• DOI: 10.1002/ijgo.13559
• Languages: English
• ISSNs: 0020-7292

Abstract

Abstract: Objective: To examine the associations between risk of pre‐eclampsia and pregnancy levels of maternal 25‐hydroxyvitamin D (25[OH]D) and oxidative stress biomarkers. Methods: A nested case–control study (n = 99; 34 cases; 65 controls) within a prospective pregnancy cohort. Maternal 25(OH)D and oxidative stress markers (six isomers of F2 ‐isoprostanes; F2 ‐isoPs) were measured in plasma at 12–18 and 24–26 gestational weeks. Vitamin D deficiency was defined as 25[OH]D less than 50 nmol/L. Results: Maternal vitamin D deficiency was associated with increased 8‐iso‐PGF2α ( P = 0.037), 15( R )‐PGF2α ( P = 0.004), (±)5‐iPF2α ‐VI ( P = 0.026) at 12–18 weeks. Vitamin D deficiency was inversely associated with 8‐iso‐PGF2α ( P = 0.019) and (±)5‐iPF2α ‐VI isomer ( P = 0.010) at 24–26 weeks. Both maternal vitamin D deficiency (adjusted odds ratio [aOR], 4.79; 95% confidence interval [CI], 1.67–13.75) and increased (±)5‐iPF2α ‐VI (aOR, 2.46; 95% CI, 1.16–5.22) at 24–26 weeks were associated with risk of pre‐eclampsia. However, the interaction test between 25(OH)D and (±)5‐iPF2α ‐VI was not significant ( P = 0.143). Conclusion: Plasma 25(OH)D below 50 nmol/L was associated with increased oxidative stress levels during pregnancy as measured by two F2 ‐isoP isomers, including the well‐studied marker 8‐iso‐PGF2α . Whether vitamin D‐induced oxidative stress mediates the risk of pre‐eclampsia warrants future study. Synopsis: In pregnancy, plasma 25‐hydroxyvitamin D levels lower than 50 nmol/L were associated with both increased oxidative stress measured as F2 ‐isoprostanes and increased risk of pre‐eclampsia.