Understanding giant cell sarcoma of the head and neck: A population‐based study. Issue 9 (14th June 2021)

• Record Type: Journal Article
• Authors: Sawhney, Rohan; Ahsanuddin, Salma; Sheorey, Lena; Wassef, David W.; Baredes, Soly; Park, Richard Chan Woo
• Is Part Of: Head & neck. Volume 43:Issue 9(2021)
• Page Start: 2786
• Page End: 2794
• Publication Date: 2021-06-14
• Subjects: head and neck -- head and neck chemotherapy -- head and neck cutaneous -- head and neck radiation therapy -- head and neck sarcoma; Head -- Diseases -- Periodicals; Neck -- Diseases -- Periodicals; Head -- Periodicals; Neck -- Periodicals; Face -- Periodicals; 617.51059
• DOI: 10.1002/hed.26765
• Languages: English
• ISSNs: 1043-3074

Abstract

Abstract: Background: Giant cell sarcomas (GCS) are rare head and neck neoplasms. Methods: The Surveillance, Epidemiology, and End Results (SEER) database was analyzed for all patients who have been diagnosed with GCS from 1973 to 2014. Results: Four hundred and forty cases of GCS of the head and neck were identified. The average age at diagnosis was 74.4 years, 86.8% were white, 82.5% were male, 70.7% were insured, and 88.2% lived in an urban metropolitan region. Connective tissue was the most frequent primary site (42.5%). The 5Y‐DSS rate was 91.1%, while the 5Y‐OS was 54.6% for all cases. Patients treated with surgery alone had the highest 5Y‐DSS rate of 94.5. T‐classification odds ratio was a significant predictor of survival accounting for confounding variables on multivariate analysis. Conclusions: GCS presents most frequently in connective tissue of the head and neck with overall high probability of survival. The treatment of choice is surgery alone.