Analysis of aluminium in rat following administration of allergen immunotherapy using either aluminium or microcrystalline-tyrosine-based adjuvants. (March 2016)

• Record Type: Journal Article
• Authors: McDougall, Stuart A; Heath, Matthew D; Kramer, Matthias F; Skinner, Murray A
• Is Part Of: Bioanalysis. Volume 8:Number 6(2016)
• Page Start: 547
• Page End: 556
• Publication Date: 2016-03
• Subjects: adjuvant -- ADME -- body burden -- ICP-MS -- ICP-MS sample digestion -- SCIT -- subcutaneous -- tiered approach -- tissue distribution; Drugs -- Analysis -- Periodicals; 615.19005
• DOI: 10.4155/bio.16.10
• Languages: English
• ISSNs: 1757-6180

Abstract

Background: Investigation into the absorption, distribution and elimination of aluminium in rat after subcutaneous aluminium adjuvant formulation administration using ICP-MS is described.Method & results: Assays were verified under the principles of a tiered approach. There was no evidence of systemic exposure of aluminium, in brain or in kidney. Extensive and persistent retention of aluminium at the dose site was observed for at least 180 days after administration.Conclusion: This is the first published work that has quantified aluminium adjuvant retention based on the quantity of aluminium delivered in a typical allergy immunotherapy course. The results indicate that the repeated administration of aluminium-containing adjuvants will likely contribute directly and significantly to an individual's body burden of aluminium.