Multiple interactions between melatonin and non‐coding RNAs in cancer biology. (16th July 2021)

• Record Type: Journal Article
• Authors: Maleki, Masomeh; Khelghati, Nafiseh; Alemi, Forough; Younesi, Simin; Asemi, Zatollah; Abolhasan, Rozita; Bazdar, Mahtab; Samadi‐Kafil, Hossein; Yousefi, Bahman
• Is Part Of: Chemical biology & drug design. Volume 98:Number 3(2021)
• Page Start: 323
• Page End: 340
• Publication Date: 2021-07-16
• Subjects: cancer -- lncRNA -- Melatonin -- miRNA; Drugs -- Design -- Periodicals; Pharmaceutical chemistry -- Periodicals; Biochemistry -- Periodicals; 615.19005
• DOI: 10.1111/cbdd.13849
• Languages: English
• ISSNs: 1747-0277

Abstract

Abstract: The melatonin hormone secreted by the pineal gland is involved in physiological functions such as growth and maturation, circadian cycles, and biological activities including antioxidants, anti‐tumor, and anti‐ischemia. Melatonin not only interacts with proteins but also has functional effects on regulatory RNAs such as long non‐coding RNAs (lncRNAs) and microRNAs (miRNAs). In this study, we overview various physiological and pathological conditions affecting melatonin through lncRNA and miRNA. The information compiled herein will serve as a solid foundation to formulate ideas for future mechanistic studies on melatonin. It will also provide a chance to more clarify the emerging functions of the non‐coding transcriptome. Abstract : The hormone melatonin, which is secreted by the pineal gland, has anti‐invasive and anti‐metastatic effects on malignant cells by modulating the expression and functions of non‐coding RNAs (ncRNAs). The complex relationship between MT treatment and its effect on ncRNAs expression helps to find new treatment strategies based on endogenous compounds.