Novel therapeutics for hydrocephalus: Insights from animal models. (20th June 2021)

• Record Type: Journal Article
• Authors: Wang, Chuansen; Wang, Xiaoqiang; Tan, Changwu; Wang, Yuchang; Tang, Zhi; Zhang, Zhiping; Liu, Jingping; Xiao, Gelei
• Is Part Of: CNS neuroscience & therapeutics. Volume 27:Number 9(2021)
• Page Start: 1012
• Page End: 1022
• Publication Date: 2021-06-20
• Subjects: animal models -- cerebrospinal fluid -- hydrocephalus -- nonsurgical treatment -- subarachnoid space; Neuropharmacology -- Periodicals; Central nervous system -- Diseases -- Effect of drugs on -- Periodicals; 612.8
• DOI: 10.1111/cns.13695
• Languages: English
• ISSNs: 1755-5930

Abstract

Abstract: Hydrocephalus is a cerebrospinal fluid physiological disorder that causes ventricular dilation with normal or high intracranial pressure. The current regular treatment for hydrocephalus is cerebrospinal fluid shunting, which is frequently related to failure and complications. Meanwhile, considering that the current nonsurgical treatments of hydrocephalus can only relieve the symptoms but cannot eliminate this complication caused by primary brain injuries, the exploration of more effective therapies has become the focus for many researchers. In this article, the current research status and progress of nonsurgical treatment in animal models of hydrocephalus are reviewed to provide new orientations for animal research and clinical practice. Abstract : Inflammation, fibrosis, iron overload, etc., play an important role in the development of hydrocephalus. By targeting these mechanisms, researchers have discovered a series of drugs that have therapeutic effects on hydrocephalus.