The double‐edged sword of Tregs in M tuberculosis, M avium, and M. abscessus infection. Issue 1 (12th March 2021)

• Record Type: Journal Article
• Authors: Verma, Deepshikha; Chan, Edward D.; Ordway, Diane J.
• Is Part Of: Immunological reviews. Volume 301:Issue 1(2021)
• Page Start: 48
• Page End: 61
• Publication Date: 2021-03-12
• Subjects: Immunity -- Mycobacterium abscessus -- Mycobacterium avium -- Mycobacterium tuberculosis; Immunology -- Periodicals; Transplantation of organs, tissues, etc -- Periodicals; 616.079
• DOI: 10.1111/imr.12959
• Languages: English
• ISSNs: 0105-2896

Abstract

Abstract: Immunity against different Mycobacteria species targeting the lung requires distinctly different pulmonary immune responses for bacterial clearance. Many parameters of acquired and regulatory immune responses differ quantitatively and qualitatively from immunity during infection with Mycobacteria species. Nontuberculosis Mycobacteria species (NTM) Mycobacterium avium‐ (M avium), Mycobacterium abscessus‐(M abscessus), and the Mycobacteria species Mycobacterium tuberculosis‐(Mtb) . Herein, we discuss the potential implications of acquired and regulatory immune responses in the context of animal and human studies, as well as future directions for efforts to treat Mycobacteria diseases.