696 Delay of Gastric Emptying by 13C-Acetate Breath Test Related to Orthopaedic Scoliosis in Neurologically Impaired Patients with Gastroesophageal Reflux. (October 2012)

• Record Type: Journal Article
• Authors: Okada, T; Honda, S; Miyagi, H; Taketomi, A
• Is Part Of: Archives of disease in childhood. Volume 97(2012)Supplement 2
• Page Start: A201
• Page End: A201
• Publication Date: 2012-10
• Subjects: Children -- Diseases -- Periodicals; Infants -- Diseases -- Periodicals; 618.920005
• DOI: 10.1136/archdischild-2012-302724.0696
• Languages: English
• ISSNs: 0003-9888

Abstract

Abstract : Background and Aims: Delayed gastric emptying often occurs in patients with gastroesophageal reflux (GER) due to neurological impairment (NI). The aim of this study was to evaluate gastric emptying of liquids in patients with symptomatic GER using the 13 C-acetate breath test (ABT), and to compare the gastric emptying rates with the severity of orthopaedic scoliosis between patients without and with NI. Methods: Sixteen patients were divided into 2 groups; group 1 without NI (6 patients) and group 2 with NI (10 patients). The liquid test meal consisted of Racol TM (5 ml/kg) mixed with 13 C-acetate (50 mg for infants, 100 mg for children, and 150 mg for adolescents). Breath samples were collected for 13 CO2 measurement before the intake of the meal, every 15 minutes during the first 2 hours after the meal and every 30 minutes thereafter to assess the ingestion of 13 C-acetate and Racol TM . 13 CO2 was measured using a gas chromatograph-isotope ratio mass spectrometer. The results were expressed as % of 13 C expired per hour and cumulative 13 C excretion over a 3-hour period. The severity of orthopaedic scoliosis was quantified by Cobb angle. Results: Statistical relations were age and half excretion time in 13 C-ABT (t1/2 ex), p=0.0649; age and groups with or without NI, p=0.00018; age and Cobb angle of scoliosis on plain XP, p=0.0087; and severe Cobb angle ≥ 30 degree and t1/2, p=0.1962. Conclusion: According to 13 C-ABT, the delayed gastric emptying in patients with GER due to NI was related to severe orthopaedic scoliosis.