708 Prevalence of Fat-Soluble Vitamin Deficiencies in Children with Cystic Fibrosis. (October 2012)

• Record Type: Journal Article
• Authors: Gupta, AK; Ng, V; Garside, J
• Is Part Of: Archives of disease in childhood. Volume 97(2012)Supplement 2
• Page Start: A204
• Page End: A204
• Publication Date: 2012-10
• Subjects: Children -- Diseases -- Periodicals; Infants -- Diseases -- Periodicals; 618.920005
• DOI: 10.1136/archdischild-2012-302724.0708
• Languages: English
• ISSNs: 0003-9888

Abstract

Abstract : Background: Malabsorption of fat-soluble vitamins is likely in most patients with cystic fibrosis, particularly those who are pancreatic insufficient. Low vitamin levels are associated with poorer clinical status, and reduced lung function. Since the introduction of improved pancreatic enzymes, normal to high fat diets and routine vitamin supplementation, clinical evidence of fat-soluble vitamin deficiency is rarely seen. Aim: To determine the prevalence of fat-soluble vitamin deficiencies in children with cystic fibrosis in Calderdale and Huddersfield NHS Trust. Method: Retrospective analysis of vitamin levels performed in children with cystic fibrosis in Calderdale and Huddersfield Trust over a period of six years. Data was available for 19 out of 22 children with cystic fibrosis. Results of plasma vitamin A, D (Total 25 OH Vit D) and E levels for these children were collected on a pre-designed proforma. Results: Vitamin A, D and E levels were checked for a total of 75, 75 and 76 times respectively over a period of six years. Vitamin E levels were normal. Vit A levels were subnormal on two occasions. However, Vitamin D levels were sub-optimal (< 60nmol/l) on forty occasions and amongst them levels were below 20 nmol/l on three occasions. Conclusion: Sub-optimal Vitamin D levels are still very common in children with cystic fibrosis despite routine vitamin supplementation.