Confocal Laser Endomicroscopy: Applications in Clinical and Translational Science—A Comprehensive Review. (29th December 2012)

• Record Type: Journal Article
• Authors: Goetz, Martin
• Other Names: Amatya V. J. Academic Editor.; Drut R. Academic Editor.; Kovács T. Academic Editor.; Wincewicz A. Academic Editor.
• Is Part Of: ISRN pathology. Volume 2012(2012)
• Publication Date: 2012-12-29
• Subjects: Pathology -- Periodicals; Pathology; Pathology; Electronic journals; Periodical; Fulltext; Internet Resources; Periodicals; Periodicals; 616.07
• DOI: 10.5402/2012/387145
• Languages: English
• ISSNs: 2090-570X

Abstract

Abstract : Confocal laser endomicroscopy (CLE) is a novel tool in the endoscopist's armamentarium. It allows on-site histological information. The ability of gastroenterologists to interpret such microscopic information has been demonstrated in multiple studies from the upper and lower gastrointestinal tract. Recently, the field of application has expanded to provide hepatobiliary and intra-abdominal CLE imaging. CLE allows "smart, " targeted biopsies and is able to guide endoscopic interventions. But CLE is also translational in its approach and permits functional imaging that significantly impacts on our understanding of gastrointestinal diseases. Molecular imaging with CLE allows detection and characterization of lesions and may even be used for prediction of response to targeted therapy. This paper provides a comprehensive review over current applications of CLE in clinical applications and translational science.