Regulation of Immune Responses by Histone Deacetylase Inhibitors. (18th March 2012)

• Record Type: Journal Article
• Authors: Licciardi, Paul V.; Karagiannis, Tom C.
• Other Names: Bosly A. Academic Editor.; Panizo C. Academic Editor.
• Is Part Of: ISRN hematology. Volume 2012(2012)
• Publication Date: 2012-03-18
• Subjects: Hematology -- Periodicals; Hematologic Diseases; Hematology; Hematology; Electronic journals; Periodical; Periodicals; Fulltext; Internet Resources; Periodicals; 616.15
• DOI: 10.5402/2012/690901
• Languages: English
• ISSNs: 2090-441X

Abstract

Abstract : Both genetic and epigenetic factors are important regulators of the immune system. There is an increasing body of evidence attesting to epigenetic modifications that influence the development of distinct innate and adaptive immune response cells. Chromatin remodelling via acetylation, methylation, phosphorylation, and ubiquitination of histone proteins as well as DNA, methylation is epigenetic mechanisms by which immune gene expression can be controlled. In this paper, we will discuss the role of epigenetics in the regulation of host immunity, with particular emphasis on histone deacetylase inhibitors. In particular, the role of HDAC inhibitors as a new class of immunomodulatory therapeutics will also be reviewed.