Detection and Control of Prion Diseases in Food Animals. (29th February 2012)

• Record Type: Journal Article
• Authors: Hedlin, Peter; Taschuk, Ryan; Potter, Andrew; Griebel, Philip; Napper, Scott
• Other Names: Harasawa R. Academic Editor.; Thanawongnuwech R. Academic Editor.
• Is Part Of: ISRN veterinary science. Volume 2012(2012)
• Publication Date: 2012-02-29
• Subjects: Veterinary medicine -- Periodicals; Veterinary Medicine; Veterinary medicine; Periodical; Periodicals; Electronic journals; Fulltext; Internet Resources; Periodicals; 636.089
• DOI: 10.5402/2012/254739
• Languages: English
• ISSNs: 2090-4452

Abstract

Abstract : Transmissible spongiform encephalopathies (TSEs), or prion diseases, represent a unique form of infectious disease based on misfolding of a self-protein (PrP C ) into a pathological, infectious conformation (PrP Sc ). Prion diseases of food animals gained notoriety during the bovine spongiform encephalopathy (BSE) outbreak of the 1980s. In particular, disease transmission to humans, to the generation of a fatal, untreatable disease, elevated the perspective on livestock prion diseases from food production to food safety. While the immediate threat posed by BSE has been successfully addressed through surveillance and improved management practices, another prion disease is rapidly spreading. Chronic wasting disease (CWD), a prion disease of cervids, has been confirmed in wild and captive populations with devastating impact on the farmed cervid industries. Furthermore, the unabated spread of this disease through wild populations threatens a natural resource that is a source of considerable economic benefit and national pride. In a worst-case scenario, CWD may represent a zoonotic threat either through direct transmission via consumption of infected cervids or through a secondary food animal, such as cattle. This has energized efforts to understand prion diseases as well as to develop tools for disease detection, prevention, and management. Progress in each of these areas is discussed.