Inferring Biologically Relevant Models: Nested Canalyzing Functions. (12th June 2012)

• Record Type: Journal Article
• Authors: Hinkelmann, Franziska; Jarrah, Abdul Salam
• Other Names: Chow J. Academic Editor.; Fellman J. Academic Editor.
• Is Part Of: ISRN biomathematics. Volume 2012(2012)
• Publication Date: 2012-06-12
• Subjects: Biomathematics -- Periodicals; Models, Biological; Biometry; Biomathematics; Electronic journals; Periodicals; Periodicals; Fulltext; Internet Resources; Periodicals; 570.151
• DOI: 10.5402/2012/613174
• Languages: English
• ISSNs: 2090-7702

Abstract

Abstract : Inferring dynamic biochemical networks is one of the main challenges in systems biology. Given experimental data, the objective is to identify the rules of interaction among the different entities of the network. However, the number of possible models fitting the available data is huge, and identifying a biologically relevant model is of great interest. Nested canalyzing functions, where variables in a given order dominate the function, have recently been proposed as a framework for modeling gene regulatory networks. Previously, we described this class of functions as an algebraic toric variety. In this paper, we present an algorithm that identifies all nested canalyzing models that fit the given data. We demonstrate our methods using a well-known Boolean model of the cell cycle in budding yeast.