Systemic effects of whole-body cooling to 35, 33 and 30 deg c in a piglet model of perinatal asphxyia. (7th June 2011)

• Record Type: Journal Article
• Authors: Faulkner, S; Chandrasekaran, M; Kerenyi, A; Kelen, D; Price, D; Bainbridge, A; Cady, E; Golay, X; Robertson, N J
• Is Part Of: Archives of disease in childhood. Volume 96(2011)Supplement 1
• Page Start: Fa13
• Page End: Fa14
• Publication Date: 2011-06-07
• Subjects: Infants -- Diseases -- Periodicals; Newborn infants -- Diseases -- Periodicals; Fetus -- Diseases -- Periodicals; 618.920105
• DOI: 10.1136/adc.2011.300160.42
• Languages: English
• ISSNs: 1359-2998

Abstract

Abstract : Background: Therapeutic hypothermia reduces neurological damage and improves survival in neonatal encephalopathy. Despite treatment, however, 50% infants have adverse outcomes. Clinical trials are investigating lower cooling temperatures as tailoring cooling may be beneficial. Objective: To assess systemic effects of cooling to 35, 33 and 30°C in a piglet model of perinatal asphyxia. Design/methods: 28 male piglets, <24 h, underwent hypoxia-ischaemia and randomized (groups n=7), with intervention from 2 to 26 h to (i) normothermia; (ii) hypothermia (35°C); (iii) hypothermia (33.5°C); intravenous) hypothermia (30°C). Heart rate (HR), mean arterial blood pressure (MABP) and rectal temperature (Trec) were recorded continuously; blood chemistry every 6 h. Results: Five animals in the 30°C group died before 48 h due to cardiac arrest, no piglets died prematurely in other groups. During cooling, HR was similar at 30°C versus 35 and 33.5°C and MABP did not differ between groups. However, inotrope and volume replacement were higher at 30°C versus all other groups (p<0.001). Blood pH was lower at 12 and 24 h (p<0.001) at 30°C versus all other groups (figure 1A ). Blood glucose, lactate and BE were abnormal at 24 h (all p< 0.05) at 30°C versus all other groups (figures 1B–D ). Conclusions: Cooling to 30°C required extensive cardiovascular support and led to significant metabolic derangement and more cardiac arrests. Despite similar MABP in all groups, systemic effects at 30°C were considerable and may be deleterious to the brain.