Retinopathy of prematurity in English neonatal units: a national population-based analysis using NHS operational data. Issue 3 (20th December 2013)

• Record Type: Journal Article
• Authors: Wong, Hilary S; Santhakumaran, Shalini; Statnikov, Yevgeniy; Gray, Daniel; Watkinson, Michael; Modi, Neena
• Other Names: Kadalraja R author non-byline.; Kefas J author non-byline.; Srinnel S author non-byline.; Ramesh C author non-byline.; Rackham O author non-byline.; Brearey S author non-byline.; Thirumurugan A author non-byline.; Losa I author non-byline.; McBride T author non-byline.; Zipitis C author non-byline.; Amegavie L author non-byline.; Moise J author non-byline.; Zipitis C author non-byline.; Yadan M author non-byline.; Maddock N author non-byline.; Moise J author non-byline.; Edi-Osagie N author non-byline.; Heal C author non-byline.; Birch J author non-byline.; Al-Zidgali F author non-byline.; Hasib A author non-byline.; Kisat H author non-byline.; Soe A author non-byline.; Long D author non-byline.; Fedee J author non-byline.; Lama M author non-byline.; Gupta R author non-byline.; Rawlingson de Boer RC author non-byline.; Rao P author non-byline.; Blake K author non-byline.; Bhaduri AK author non-byline.; Halahakoon C author non-byline.; Deshpande Mohite A author non-byline.; Tewary KK author non-byline.; Palmer K author non-byline.; Gallagher A author non-byline.; Nycyk J author non-byline.; Simmons P author non-byline.; Morgen I author non-byline.; Underhill HC author non-byline.; Mahesh Babu R N author non-byline.; Dalton S author non-byline.; Dixon H author non-byline.; James M author non-byline.; Jayalal V author non-byline.; Dyke M author non-byline.; Babiker S author non-byline.; Soe T author non-byline.; Rubin S author non-byline.; Ogilvy-Stuart A author non-byline.; Evans I author non-byline.; Wickham T author non-byline.; van Someren V author non-byline.; Watkin S author non-byline.; Blumberg R author non-byline.; Sharief N author non-byline.; Aladangady N author non-byline.; Sharma B author non-byline.; Sullivan C author non-byline.; Alsford L author non-byline.; Sharma B author non-byline.; Khan A author non-byline.; Hamdan S author non-byline.; Ahmed JS author non-byline.; Foo A author non-byline.; Talekar R author non-byline.; Adiotomre P author non-byline.; Gibson A author non-byline.; Thomas M author non-byline.; Mathur R author non-byline.; Cruwys M author non-byline.; Mannix P author non-byline.; Ariff H author non-byline.; Garbasa M author non-byline.; Lal M author non-byline.; Bosman D author non-byline.; Fenton A author non-byline.; Bolton AR author non-byline.; Abu-Harb M author non-byline.; Verber I author non-byline.; Olivier J author non-byline.; Larson J author non-byline.; Cherinet Y author non-byline.; Munyard P author non-byline.; Osbourne N author non-byline.; Raman M author non-byline.; Watts; T author non-byline.; Hannam S author non-byline.; Walter S author non-byline.; Kuna J author non-byline.; Chang YL author non-byline.; Shephard R author non-byline.; Lindo D author non-byline.; Calvert S author non-byline.; Wigfield R author non-byline.; Wylie P author non-byline.; Misra I author non-byline.; Shettihalli N author non-byline.; Khashu M author non-byline.; Hall M author non-byline.; Groves C author non-byline.; de Halpert P author non-byline.; Schapira D author non-byline.; Kinsey S author non-byline.; Butterworth S author non-byline.; Garg A author non-byline.; Whitehead G author non-byline.; Sanghavi R author non-byline.; Whincup G author non-byline.; Khader K author non-byline.; Mallik A author non-byline.; Amess; P author non-byline.; Godden C author non-byline.; Reynolds P author non-byline.; Brannan N author non-byline.; Noble V author non-byline.; Rao AS author non-byline.; Wardle S author non-byline.; Ratnayaka M author non-byline.; Holman J author non-byline.; Zengeya S author non-byline.; Jones S author non-byline.; Wach R author non-byline.; Tooley J author non-byline.; Mann RJ author non-byline.; Eaton M author non-byline.; Babirecki M author non-byline.; Seal S author non-byline.; Schwartz K author non-byline.; Gibson D author non-byline.; Jampala C author non-byline.; Pairaudeau P author non-byline.; Miall L author non-byline.; Shyamannr K author non-byline.; Qunib M author non-byline.;
• Is Part Of: Archives of disease in childhood. Volume 99:Issue 3(2014)
• Page Start: F196
• Page End: F202
• Publication Date: 2013-12-20
• Subjects: Retinopathy of prematurity -- Preterm infants -- Vision screening -- Electronic health records -- Practice guidelines; Infants -- Diseases -- Periodicals; Newborn infants -- Diseases -- Periodicals; Fetus -- Diseases -- Periodicals; 618.920105
• DOI: 10.1136/archdischild-2013-304508
• Languages: English
• ISSNs: 1359-2998

Abstract

Abstract : Objectives: To report on retinopathy of prematurity (ROP) screening compliance against a national guideline, factors associated with non-compliance and effect on ROP treatment. Design: National cohort study using operational NHS data from the National Neonatal Research Database (NNRD) for the period 2009–2011. Setting: 161 (94%) neonatal units in England. Population: Infants born below 32 weeks' gestation and/or with a birth weight below 1501 g. Main outcome measures: ROP screening status ('on-time', 'early', 'late', 'unknown') and associated infant and neonatal unit characteristics, ROP treatment. Results: The proportion of infants screened on-time increased over the study period (p<0.001). Of 19 821 eligible infants, 7602 (38.4%) were recorded to have received ROP screening in accordance with the national guideline; 7474 (37.8%) received screening outside the recommended time period; data were missing for 4745 (16.7%) infants. For 16 411 infants in neonatal care during the recommended screening period, late screening was significantly associated with lower gestational age (relative risk ratio (RRR) (95% credible interval) for late versus on-time screening 0.83 (0.80 to 0.86) for each increased week of gestation) and care in a neonatal unit providing less than 500 days of intensive care per annum (2.48 (0.99 to 4.99)). Infants screened late were almost 40% more likely to receive ROP treatment (OR (95% CI) 1.36 (1.05 to 1.76)). Conclusions: Understanding organisational differences between neonatal units may help improve ROP screening. Patient-level electronic NHS clinical data offer opportunity for future rapid, low cost, population-based evaluations but require improved data entry.