Mechanical property, antibacterial activity and cytocompatibility of a PMMA-based bone cement loaded with clindamycin for orthopaedic surgeries. (29th July 2021)

• Record Type: Journal Article
• Authors: Pahlevanzadeh, F.; Bakhsheshi-Rad, H.R.; Kasiri-Asgarani, M.; Emadi, R.; Omidi, M.; Ismail, A.F.; Afrand, M.; Berto, F.
• Is Part Of: Materials technology. Volume 36:Number 9(2021)
• Page Start: 564
• Page End: 573
• Publication Date: 2021-07-29
• Subjects: PMMA-based bone cement -- clindamycin -- mechanical properties -- antibacterial activity -- biocompatibility; Materials -- Periodicals; Materials science -- Periodicals; Materials -- Technological innovations -- Periodicals; 620.1105
• DOI: 10.1080/10667857.2020.1780812
• Languages: English
• ISSNs: 1066-7857

Abstract

ABSTRACT: Local delivery of antibiotics utilising bone cement is a well-known approach for controlling postoperative infections related to implant. 1, 5 and 10 wt.% of clindamycin (Cli) was embedded into polymethylmethacrylate (PMMA)–based bone cement for inhibiting postsurgical infection. Clindamycin antibiotic drug was homogeneously embedded into the matrix of PMMA-based cement. The results revealed that the fabricated PMMA-based cement loaded with Cli presented a high compressive strength (~120 MPa). The PMMA-based cement loaded with low Cli presented better cytocompatibility compared with its counterpart loaded with high Cli owing to the better cell attachment on the surface of the cement with a lower release of Cli. The embedding of Cli into the cement improved its antibacterial performance, as implied by the considerably improved inhibition zone with amplifying Cli concentration. Taken together, PMMA-based cement loaded with 1–5 wt% Cli might be a promising antimicrobial bone cement to be employed in orthopaedic surgeries.