Ranking procedures for repeated measures designs with missing data: Estimation, testing and asymptotic theory. (January 2022)

• Record Type: Journal Article
• Authors: Rubarth, Kerstin; Pauly, Markus; Konietschke, Frank
• Is Part Of: Statistical methods in medical research. Volume 31:Number 1(2022)
• Page Start: 105
• Page End: 118
• Publication Date: 2022-01
• Subjects: Rank statistics -- nonparametric methods -- relative effect -- repeated measurements -- missing data; Medicine -- Research -- Statistical methods -- Periodicals; Research -- Periodicals; Review Literature -- Periodicals; Statistics -- methods -- Periodicals; Médecine -- Recherche -- Méthodes statistiques -- Périodiques; 610.727
• DOI: 10.1177/09622802211046389
• Languages: English
• ISSNs: 0962-2802

Abstract

We develop purely nonparametric methods for the analysis of repeated measures designs with missing values. Hypotheses are formulated in terms of purely nonparametric treatment effects. In particular, data can have different shapes even under the null hypothesis and therefore, a solution to the nonparametric Behrens-Fisher problem in repeated measures designs will be presented. Moreover, global testing and multiple contrast test procedures as well as simultaneous confidence intervals for the treatment effects of interest will be developed. All methods can be applied for the analysis of metric, discrete, ordinal, and even binary data in a unified way. Extensive simulation studies indicate a satisfactory control of the nominal type-I error rate, even for small sample sizes and a high amount of missing data (up to 30%). We apply the newly developed methodology to a real data set, demonstrating its application and interpretation.