An efficient and general method for the synthesis of stable isotope deuterium labeled phthalate esters. (26th June 2021)

• Record Type: Journal Article
• Authors: Xu, Zhongjie; Zhao, Cheng; Sun, Wen; Lei, Wen; Hu, Zuming
• Is Part Of: Journal of labelled compounds & radiopharmaceuticals. Volume 64:Number 10(2021)
• Page Start: 378
• Page End: 384
• Publication Date: 2021-06-26
• Subjects: deuterium labeled -- o‐xylene‐D10 -- phthalate esters -- plasticizer -- synthesis; Tracers (Chemistry) -- Periodicals; Radiopharmaceuticals -- Periodicals; 615.8424
• DOI: 10.1002/jlcr.3930
• Languages: English
• ISSNs: 0362-4803

Abstract

Abstract : An efficient and general synthetic route of deuterium‐labeled phthalate esters is described with high isotopic enrichment and excellent chemical purities using inexpensive and readily available o‐xylene‐D10 as labeled starting material. The structures and isotope‐abundance were confirmed via 1 H NMR and mass spectrometry. These deuterium labeled phthalate esters can be used as analytical reference standards for the detection of plasticizer residues in soil, water, food, plastic products, etc. Abstract : We have developed an efficient and general synthetic route of deuterium labeled phthalate esters, which were prepared from o‐xylene‐D10 in high isotopic enrichment and excellent chemical purities. The products can be used as analytical reference standards for the detection of plasticizer residues in soil, water, food, etc. The advantages of the method are high isotopic enrichment and chemical purity, facile processing, and low costs.