Synthetic Cannabinoids 5F-QUPIC and MDMB-CHMICA in Plant Material – Identification and Quantification by Gas Chromatography – Mass Spectrometry (GC-MS), Nuclear Magnetic Resonance (NMR), and High-Performance Liquid Chromatography with Diode Array Detection (HPLC-DAD). (15th July 2021)

• Record Type: Journal Article
• Authors: Ivanov, Ivo D.; Stoykova, Silviya S.; Burdzhiev, Nikola T.; Pantcheva, Ivayla N.; Atanasov, Vasil N.
• Is Part Of: Analytical letters. Volume 54:Number 16(2021)
• Page Start: 2600
• Page End: 2610
• Publication Date: 2021-07-15
• Subjects: 5F-QUPIC -- MDMB-CHMICA -- gas chromatography-mass spectrometry (GC-MS) -- herbal mixture -- high-performance liquid chromatography-diode array detection (HPLC-DAD) -- 8-hydroxyquinoline -- nuclear magnetic resonance (NMR) -- synthetic cannabinoids; Chemistry, Analytic -- Periodicals; Chemistry, Analytic -- Abstracts; 543
• DOI: 10.1080/00032719.2021.1879109
• Languages: English
• ISSNs: 0003-2719

Abstract

Abstract: The synthetic cannabinoids 5F-QUPIC and MDMB-CHMICA were sprayed on plant material intended for smoking and was seized as a criminal evidence. Their presence was confirmed by gas chromatography – mass spectrometry (GC-MS), and nuclear magnetic resonance (NMR). In the absence of analytical standards (indirect approach), the quantity of 5F-QUPIC in the herbal extract was determined by high-performance liquid chromatography with diode array detection (HPLC-DAD) based on total hydrolysis and measurement of the hydrolytic product (8-hydroxyquinoline) at 292 nm. The quantity of MDMB-CHMICA was determined using the ratio of 1 H-NMR signals of both compounds in methanol-d4 . 5F-QUPIC and MDMB-CHMICA in the herbal mixture were determined by the validated HPLC-DAD protocol by a direct approach with standards.