The immune dysregulations in COVID-19: Implications for the management of rheumatic diseases. Issue 5 (3rd September 2021)

• Record Type: Journal Article
• Authors: Xiao, Fan; Han, Man; Zhu, Xiaoxia; Tang, Yuan; Huang, Enyu; Zou, Hejian; Jiang, Quan; Lu, Liwei
• Is Part Of: Modern rheumatology. Volume 31:Issue 5(2021)
• Page Start: 927
• Page End: 932
• Publication Date: 2021-09-03
• Subjects: COVID-19 -- immune dysregulation -- management -- rheumatic diseases; Rheumatology -- Periodicals; 616.723005
• DOI: 10.1080/14397595.2020.1868673
• Languages: English
• ISSNs: 1439-7595

Abstract

Abstract: The pandemic of COVID-19 has caused global social impact and high health risk. Clinical observations have suggested that elevated levels of inflammatory mediators are associated with disease severities in COVID-19 patients, in which the immunological profiles indicate the hyperactivation of innate immune cells and dysregulated adaptive immune responses. The increasing prevalence and disease progression of COVID-19 has emerged as a pressing challenge for the management of rheumatic patients with immune dysregulations. Here we review the immune dysregulations in COVID-19 and discuss the management of COVID-19 patients with rheumatic diseases.