Protective effects of (-)-epigallocatechin gallate and curcumin against acrylamide toxicity. Issue 2 (7th February 2021)

• Record Type: Journal Article
• Authors: Wang, Shanshan; Wang, Hufei; Chen, Yanqiu; Liu, Jilai; He, Xiaozhen; Huang, Da; Wu, Yuanzi; Chen, Yonghai; Weng, Zuquan
• Is Part Of: Toxicological and environmental chemistry. Volume 103:Issue 2(2021)
• Page Start: 199
• Page End: 218
• Publication Date: 2021-02-07
• Subjects: Acrylamide -- genotoxicity -- developmental toxicity -- (-)- epigallocatechin gallate -- curcumin -- human lymphocytes -- zebrafish embryos; Toxicology -- Periodicals; Environmental chemistry -- Periodicals; 571.95
• DOI: 10.1080/02772248.2021.1951731
• Languages: English
• ISSNs: 0277-2248

Abstract

Abstract: Human lymphocytes as well as zebrafish embryos were used to study the toxicity of acrylamide, and the intervention effects of the dietary antioxidants (-)-epigallocatechin gallate and curcumin have been examined. The alkaline comet assay revealed that acrylamide (1, 5, 10 mmol/L) had dose-response effects on basic DNA damage and oxidative DNA damage in human lymphocytes. Exposure of zebrafish embryos to acrylamide resulted in decrease of hatching rate, and in increases of mortality and teratogenicity. (-)-Epigallocatechin gallate and curcumin reduced DNA damage and protected zebrafish embryos in the growth and development.